The Journal of Organic Chemistry

Steroids. CCLXI. 1 Microbiological Hydroxylation of Estrane Derivatives with Fusarium moniliforme

P Crabbé, C Casas-Campillo

Index: Crabbe,P.; Casas-Campillo,C. Journal of Organic Chemistry, 1964 , vol. 29, p. 2731 - 2734

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Citation Number: 17

Abstract

Incubation of estrone (Ia) with Fusarzum monzlaforme afforded 15n-hydroxyestrone (Ib). Incubation of estradiol (IIa) with the same microorganism provided 15n-hydroxyestradiol (IIc), while 66-hydroxyestradiol 3-methyl ether (I%) was obtained by microbial incubation of estradiol 3-methyl ether (IIb). The structure determination of these substances, obtained by enzymatic transformations, results from both chemical and nuclear magnetic resonance ...