Coenzyme models. 37. A crown ether flavin mimic: synthesis and properties of a flavin bearing a crown ring as a recognition site

S Shinkai, Y Ishikawa, H Shinkai, T Tsuno…

Index: Shinkai, Sheiji; Ishikawa, Yuichi; Shinkai, Hiroko; Tsuno, Takaharu; Makishima, Hiroki; et al. Journal of the American Chemical Society, 1984 , vol. 106, # 6 p. 1801 - 1808

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Citation Number: 51

Abstract

Abstract: A crown ether flavin mimic (3, 10-dimethyl-l', 4', 7', 10', 13', 16'- hexaoxacyclooctadec-2'-eno [2', 3'-i] isoalloxazine, crF1) which has within a molecule both flavin as a catalytic site and crown ring as a recognition site was synthesized. The absorption band and the fluorescence intensity of crFl decreased with increasing alkali metal concentrations. From plots of OD/OD,(or Z/Zo) vs. metal ion concentrations were ...