Journal of heterocyclic chemistry

Synthesis of unsymmetrical arylthiophenes and bithienyls via oxidative cyclization of 1, 3??butadiene??1??thiols

E Campaigne, RL White

Index: Campaigne, E.; White, R.L. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 367 - 373

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Citation Number: 11

Abstract

Abstract Oxidative cyclization of 2-mercapto-5-aryl-2, 4-pentadienoic acids with iodine produced the respective 5-aryl-2-thenoic acids. The method was also suitable for the synthesis of unsymmetrical substituted 2, 2′-bithienyls, and 2, 3′-bithienyls. The synthesis of 5-carboxy-2′-bromo-5′-phenyl-2, 3′-bithienyl from benzal-acetone demonstrated that oxidative cyclization of 1, 3-butadiene-1-thiols is a useful procedure for preparing 5′-aryl- ...