Relationship between chemical structure and anticonvulsant activity in succinimides

…, NS Nesunts, NS Buyukyan, OL Mndzhoyan…

Index: Avetisyan, S. A.; Nesunts, N. S.; Buyukyan, N. S.; Mndzhoyan, O. L.; Dzhagatspanyan, I. A.; et al. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 4 p. 309 - 313 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 4 p. 433 - 438

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Abstract

The starting p-substituted benzaldehydes (IV) were obtained by the Sommelet reaction [6] from the p-substituted benzyl chlorides (IIIa, b). Chloromethylation of the appropriate benzenes was carried out by the Blane method [8], and the optimum conditions for the preparation of (IIIa, b) in yields of 48 and 51.6% respectively, have been established (the yields reported in the literature [3, 12] are 20 and 7.2%).