In the attempt to define more accurately structure-affinity relationships for σ1 and σ2 ligands, we synthesized and tested on σ subtype receptors a series of aralkyl derivatives of 4- benzylpiperidine, in which the effect of modifications on the aralkyl moiety was studied in a systematic way. The affinity of the compounds here described varied to a great extent, with a σ2/σ1 selectivity ranging from 0.1 to 9. Thus, to confirm the ability of the piperazine ...
