2-(1H-Pyrazol-4-yl) acetic acids as CRTh2 antagonists

…, M Calbet, J Castro, T Domènech, P Eichhorn…

Index: Andres, Miriam; Bravo, Monica; Buil, Maria Antonia; Calbet, Marta; Castro, Jordi; Domenech, Teresa; Eichhorn, Peter; Ferrer, Manel; Gomez, Elena; Lehner, Martin D.; Moreno, Imma; Roberts, Richard S.; Sevilla, Sara Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3349 - 3353

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Citation Number: 7

Abstract

Prostaglandin D 2 (PGD 2 ) is derived from the metabolism of arachidonic acid by cyclooxygenases and downstream PGD 2 synthases. In the immune system, PGD 2 is mainly produced by mast cells 1 but also although at lower levels, by macrophages and Th2 lymphocytes. 2 PGD 2 binds to three different receptors, the thromboxane type prostanoid receptor (TP), 3 the PGD 2 receptor (DP, also known as DP1) 4 and the chemoattractant receptor homologous molecule ...