Novel nucleobase-modified cADPR mimics were synthesized by the application of click chemistry. Cu (I)-Huisgen cycloaddition (click reaction) was used to construct 4-amide-1, 2, 3- triazole nucleobase and connect two building blocks efficiently. A concise protection strategy was used for the synthesis of the corresponding cyclo-pyrophosphate, and the target compounds 6a and 6b were prepared within four steps.
