Catalytic Asymmetric Amination of N??Nonsubstituted α??Alkoxycarbonyl Amides: Concise Enantioselective Synthesis of Mycestericin F and G

…, S Takechi, N Kumagai, M Shibasaki

Index: Berhal, Farouk; Takechi, Sho; Kumagai, Naoya; Shibasaki, Masakatsu Chemistry - A European Journal, 2011 , vol. 17, # 6 p. 1915 - 1921

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Citation Number: 33

Abstract

Abstract In an attempt to explore the synthetic utility of a ternary asymmetric catalyst comprising La (NO 3) 3⋅ 6H 2 O, amide-based ligand (R)-L1, and D-valine tert-butyl ester HD-Val-OtBu, we investigated a catalytic, asymmetric amination of functionalized N- nonsubstituted α-alkoxycarbonyl amides using di-tert-butyl azodicarboxylate as an electrophilic aminating reagent. A highly functionalized, cyclic N-nonsubstituted α- ...