Design and synthesis of sulfur based inhibitors of matrix metalloproteinase-1.

T Fujisawa, S Odake, Y Ogawa, J Yasuda…

Index: Fujisawa, Tetsunori; Odake, Shinjiro; Ogawa, Yuji; Yasuda, Junko; Morita, Yasuo; Morikawa, Tadanori Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 2 p. 239 - 252

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Citation Number: 15

Abstract

Fibroblast collagenase (MMP-1), a member of the matrix metalloproteinases family, is believed to be a pathogenesis of arthritis, by cleaving triple-helical type II collagen in cartilage. From the similarity of the active site zinc binding mode with hydroxamate, we designed and synthesized α-mercaptocarbonyl possessing compounds (3—5), which incorporated various peptide sequences as enzyme recognition sites. The P 4–P 1 ...