2-Substituted thiazolidine-4 (R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

HT Nagasawa, DJW Goon, WP Muldoon…

Index: Nagasawa; Goon; Muldoon; Zera Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 591 - 596

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Citation Number: 116

Abstract

Medical Research Laboratories, VA Medical Center, and Department of Medicinal Chemistry, university of Minnesota, Minneapolis, Minnesota 5541 7, and Department of Surgery, Hennepin County Medical Center, Minneapolis, Minnesota 55415. Received August 11, 1983 ... A number of 2-alkyl- and 2-aryl-substituted thiazolidine-4(R)-carboxylic acids were evaluated for their protective effect against hepatotoxic deaths produced in mice by LDw ...