A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

…, KV Rajendran, J Muldoon, DG Gilheany

Index: Byrne, Peter A.; Rajendran, Kamalraj V.; Muldoon, Jimmy; Gilheany, Declan G. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 17 p. 3531 - 3537

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Citation Number: 39

Abstract

A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.