Tetrahedron Letters

Lipase-catalysed kinetic resolutions of secondary alcohols in pressurised liquid hydrofluorocarbons

AJ Ball, S Corr, J Micklefield

Index: Ball, Anthony J.; Corr, Stuart; Micklefield, Jason Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3543 - 3546

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Citation Number: 8

Abstract

Three model secondary alcohols have been subjected to enzymatic kinetic resolution using three common lipases and a typical acyl donor. The resolutions were performed in two pressurised low-boiling hydrofluorocarbons, which are novel media for enzymatic reactions, and five conventional organic solvents. In general, higher yields, ee's and rates of reaction were observed in the hydrofluorocarbons.