Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for Glycine and γ-aminobutyric acid receptors

…, D Pocar, G Pontremoli, S Pellegrino…

Index: Gelmi, Maria Luisa; Fontana, Gabriele; Pocar, Donato; Pontremoli, Guido; Pellegrino, Sara; Bombardelli, Ezio; Riva, Antonella; Balduini, Walter; Carloni, Silvia; Cimino, Mauro Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2245 - 2248

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Citation Number: 8

Abstract

New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on γ-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synthetic approaches were used with the readily available 3-O-demethylthiocolchicine (1b) and thiocolchicoside (2a). Glycosyl compounds 2a-g were obtained from 1b and 1-fluorosugars 4. 6'- ...