Synthesis of CF3??Substituted Olefins by Julia–Kocienski Olefination Using 2??[(2, 2, 2??Trifluoroethyl) sulfonyl] benzo [d] thiazole as Trifluoromethylation Agent

A Hafner, TS Fischer, S Bräse

Index: Hafner, Andreas; Fischer, Tobias S.; Braese, Stefan European Journal of Organic Chemistry, 2013 , # 35 p. 7996 - 8003

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Citation Number: 7

Abstract

Abstract A modified Julia–Kocienski protocol was investigated for the synthesis of CF 3- substituted terminal olefins. By employing a simple one-step procedure, aldehydes were converted into the corresponding CF 3-substituted olefins using 2-[(2, 2, 2-trifluoroethyl) sulfonyl] benzo [d] thiazole as the trifluoromethylation agent. This sulfone was prepared on a gram scale in two steps from inexpensive and commercially available trifluoroethanol. The ...