Mild and Selective H/D Exchange at the β Position of Aromatic α??Olefins by N??Heterocyclic Carbene–Hydride–Rhodium Catalysts

…, R Castarlenas, JJ Pérez??Torrente…

Index: Di Giuseppe, Andrea; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Lahoz, Fernando J.; Polo, Victor; Oro, Luis A. Angewandte Chemie - International Edition, 2011 , vol. 50, # 17 p. 3938 - 3942

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Citation Number: 39

Abstract

One of the major challenges in modern chemistry is the design of improved catalysts for controlled and selective CÀH functionalization.[1] In this context, H/D exchange reactions are valuable transformations for the preparation of isotopically labeled compounds that have found practical applications in mechanistic investigations of catalysis, spectroscopic analysis, or the monitoring of drug metabolism.[2] Organometallic catalysts offer the ...