The first example of a mimic of the overall thymidylate synthase reaction

PFC van der Meij, TBRA Chen, E Hilhorst…

Index: Meij, Paul F. C. van der; Chen, Tjoe B. R. A.; Hilhorst, Ellen; Waard, Eduard R. de; Pandit, Upendra K. Journal of the Chemical Society, Chemical Communications, 1987 , # 10 p. 720 - 721

Full Text: HTML

Citation Number: 0

Abstract

2-Tosyl-1,2,3,12b-tetrahydroimidazo[ 1,5-flphenanthridine functions as a mimic of the cofactor 5,lO-methylenetetrahydrofolate in transferring both a methylene moiety and a hydride equivalent (ie. an overall methyl group) to the C-5 position of a uracil derivative. ... The enzyme thymidylate synthase (EC 2.1.1.45) catalyses the conversion of 2'-deoxyuridinemonophosphate (dUMP) to 2'-deoxythymidinemonophosphate (dTMP) with the con- comitant transformation of the ...