Abstract The preparation of optically pure quaternary piperidines, both fluorinated and non- fluorinated, has been achieved from a chiral imino lactone derived from (R)-phenylglycinol. In the case of the fluorinated derivatives, the addition of (trifluoromethyl) trimethylsilane (TMSCF 3) followed by iodoamination and migration of the CF 3 group allowed access to four derivatives of α-(trifluoromethyl) pipecolic acid. A theoretical study of the CF 3-group ...
[Storcken, Roy P. M.; Panella, Lavinia; Van Delft, Floris L.; Kaptein, Bernard; Broxterman, Quirinus B.; Schoemaker, Hans E.; Rutjes, Floris P. J. T. Advanced Synthesis and Catalysis, 2007 , vol. 349, # 1-2 p. 161 - 164]
