Conclusions (R)-(-)-and (S)-(+)-fenoprofens adopt different packing arrangements inside the p-CD dimer, the R being head-to-head and the S head-to-tail. The differences are due to the effects of formation of the complex dimer and crystal-packing effects such as the means of satisfying the hydration requirements of the carboxylic acid group. Steric restrictions on the meta-substituted propionic acid group, such as the inability of the methyl group to ...
[Margolis, Brandon J.; Long, Kimberly A.; Laird, Dana L. T.; Ruble, J. Craig; Pulley, Shon R. Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2232 - 2235]