Preparation and study of derivatives and analogues of the phencyclidine molecule possessing immunosuppressive properties in vitro

…, CF Liu, F Zenone, JC Mani, JM Kamenka

Index: Ilagouma, A. T.; Dornand, J.; Liu, C. F.; Zenone, F.; Mani, J. C.; Kamenka, J. M. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 609 - 615

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Citation Number: 9

Abstract

Abstract Derivatives and analogues of the phencyclidine molecule (1-phenyl 1-(1- piperidino) cyclohexane or PCP) were prepared to investigate their immunosuppressive potency and to define the physicochemical parameters which may influence this activity recently demonstrated for PCP. Most of the tested molecules are more effective than PCP itself. In spite of lack of quantitative data, the biological activity appears to be dependent ...