Synthese de methyl-4 pyrido (3, 2-e) pyrrolo (1, 2-a) pyrazines.

JC LANCELOT, MAX ROBBA, NHUY DUNG…

Index: Lancelot; Robba; Dung; Viossat Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3248 - 3252

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Abstract

The synthesis of 4-methyl pyrido [3, 2-e] pyrrolo [1, 2-a] pyrazines was described. The starting material, 2-amino-4-methyl-3-nitropyridine, was converted into pyrrolyl derivative by using 2, 5-dimethoxytetrahydrofuran in glacial acetic aicd. Subsequent cyclization of the latter afforded the title compounds. The proton nuclear magnetic resonance spectra of the products was also studied.