Tetrahedron letters

Studies directed towards asymmetric synthesis of levobupivacaine

S Kumar, U Ramachandran

Index: Kumar, Sanjeev; Ramachandran, Uma Tetrahedron Letters, 2005 , vol. 46, # 1 p. 19 - 21

Full Text: HTML

Citation Number: 20

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... We report herein the first catalytic asymmetric synthesis of levobupivacaine. The key step involves the asymmetric alkylation of N-benzylimine glycinamide (2b). ... Levobupivacaine is obtained mainly by diastereomeric resolution of bupivacaine or its synthetic intermediates like pipecolic acid using d-tartaric ...

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