Optical isomers of rocastine and close analogs: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical …

MC Sleevi, AD Cale Jr, TW Gero…

Index: Journal of Medicinal Chemistry, , vol. 34, # 4 p. 1314 - 1328

Full Text: HTML

Citation Number: 24

Abstract

... Since the equivalent groups are assumed to occupy the same site on the receptor, the validity of both the pharmacophoric model and the fit of various compounds to it can be ver- ified in that identical chemical modification of ... Journal of Medicinal Chemistry, 1991, Vol. 34, No. ...