First preparative enantiomer resolution of pirlindole, a potent antidepressant drug

…, A Ceccato, P Hubert, J Crommen, J Géczy

Index: De Tullio, Pascal; Felikidis, Apostolos; Pirotte, Bernard; Liegeois, Jean-Francois; Stachow, Monique; Delarge, Jacques; Ceccato, Attilio; Hubert, Philippe; Crommen, Jacques; Geczy, Joseph Helvetica Chimica Acta, 1998 , vol. 81, # 3 p. 539 - 547

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Citation Number: 9

Abstract

Abstract Pirlindole is an antidepressant drug. It acts principally as reversible inhibitor of monoamine oxidase-A (RIMA) and appears relatively potent in comparison with reference drugs. Pirlindole possesses stereogenic center but is generally used as racemate. In this work, the first preparative resolution of its enantiomeric couple is described. Whereas selective crystallization of salts of chiral acid failed, two asymmetric synthetic pathways ...