N-(tert-butoxycarbonyl)-N-[4-(dimethylazaniumylidene)-1, 4-dihydropyridin-1-ylsulfonyl] azanide: a new sulfamoylating agent. Structure and reactivity toward amines

…, L Toupet, V Barragan, G Dewynter, JL Montero

Index: Winum; Toupet; Barragan; Dewynter; Montero Organic letters, 2001 , vol. 3, # 14 p. 2241 - 2243

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Citation Number: 59

Abstract

The sulfamoyl moiety is an important structural element in numerous compounds of biological interest. 1 During our efforts toward efficient synthesis of sulfamide or sulfamate derivatives, we demonstrated that chlorosulfonyl isocyanate (CSI), the strongest bielectrophile, is the reagent of choice for the preparation of such compounds. 2 Previously, we demonstrated that according to the difference of reactivity between both the isocyanate and the chlorosulfonic acid ...