Synthesis, radiolabeling, and biological evaluation of (R)-and (S)-2-amino-3-[18F] fluoro-2-methylpropanoic acid (FAMP) and (R)-and (S)-3-[18F] fluoro-2-methyl-2-N-( …

W Yu, J McConathy, L Williams, VM Camp…

Index: Yu, Weiping; McConathy, Jonathan; Olson, Jeffrey; Camp, Vernon M.; Goodman, Mark M. Journal of Medicinal Chemistry, 2007 , vol. 50, # 26 p. 6718 - 6721

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Citation Number: 25

Abstract

The non-natural amino acids (R)-and (S)-2-amino-3-fluoro-2-methylpropanoic acid 5 and (R)-and (S)-3-fluoro-2-methyl-2-N-(methylamino) propanoic acid 8 were synthesized in shorter reaction sequences than in the original report starting from enantiomerically pure (S)- and (R)-α-methyl-serine, respectively. The reaction sequence provided the cyclic sulfamidate precursors for radiosynthesis of (R)-and (S)-[18F] 5 and (R)-and (S)-[18F] 8 in ...