New chalcones containing nucleosides exhibiting in vitro anti-cancer activities

L Van Chinh, T Ngoc Hung, N Thi Nga…

Index: Van Chinh, Luu; Hung, Truong Ngoc; Nga, Nguyen Thi; Phong, Le; Huong, Le Mai; Ha, Tran Thi Hong; Kim, Soo Un; Vu, Tran Khac Letters in Organic Chemistry, 2014 , vol. 11, # 7 p. 534 - 545

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Abstract

Twenty-one new chalcones 9a-m (excluding 9e, 9j and 9l) and 10a-m (excluding 10j and 10l), containing nucleobases were synthesized from 2'-hydroxyacetophenone (1) by the reactions including chloromethylation, nucleophilic substitution with thymine and uracil, and Claisen-Schmidt reactions. These new chalcones were evaluated for in vitro cytotoxicity against five human cancer cell lines: SK-LU-1, Hep-G2, MCF7, SW480 and P388. The ...