Synthesis of Furan and Thiophene Analogs of Duocarmycin SA.

H MuRATAKE, K Okabe, M TAKAHAsHI…

Index: Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 799 - 806

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Citation Number: 24

Abstract

... in 15a and 15h was changed to the tert-butyl ester as in 16a”) and 16b in Nmom 0 y. Ohde R OMe duocarmycin SA (1): X=NH, R=H furan analog 6: X=O, R=Me thiophene analog 7: X=S, R=H S: X=NH, O, S; Y=NH, 0, S Chart 1 © 1997 Pharmaceutical Society of ... 800 Vol. 45, No. ...