Abstract: Full details of the first total syntheses of (+)-P-3A (l), epi-(-)-P-3A (2), and (-)- desacetamido P-3A (3) are disclosed. Key strategic elements of the approach include the implementation of an inverse electron demand [4+ 21 cycloaddition reaction of 2, 4, 6-tris (ethoxycarbonyl)-1, 3, 5-triazine with in situ generated 1, l-diaminoethene for one-step preparation of an appropriately functionalized pyrimdine core and the subsequent use of a ...
