New antifungal scaffold derived from a natural pharmacophore: Synthesis of α-methylene-γ-butyrolactone derivatives and their antifungal activity against …

F Jun-Tao, W De-Long, W Yong-Ling, Y He…

Index: Jun-Tao, Feng; De-Long, Wang; Yong-Ling, Wu; He, Yan; Xing, Zhang Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 15 p. 4393 - 4397

Full Text: HTML

Citation Number: 9

Abstract

Thirty new and thirty-four known analogues were designed and synthesized to improve the potential use of the α-methylene-γ-butyrolactone ring, a natural pharmacophore. All structures were confirmed by 1H and 13C NMR, MS, and single-crystal X-ray diffraction analyses. The results of antifungal and cytotoxic activity indicated that the synthesized analogues showed significant inhibitory activity and limited selectivity. Compound 45 ...