Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets

AS Mayhoub, L Marler, TP Kondratyuk, EJ Park…

Index: Mayhoub, Abdelrahman S.; Marler, Laura; Kondratyuk, Tamara P.; Park, Eun-Jung; Pezzuto, John M.; Cushman, Mark Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 510 - 520

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Citation Number: 32

Abstract

Chemoprevention is an approach to decrease cancer morbidity and mortality through inhibition of carcinogenesis and prevention of disease progression. Although the trans stilbene derivative resveratrol has chemopreventive properties, its action is compromised by weak non-specific effects on many biological targets. Replacement of the stilbene ethylenic bridge of resveratrol with a 1, 2, 4-thiadiazole heterocycle and modification of the ...