Tetrahedron letters

Solvent-free catalytic preparation of 1, 1-diacetates from aldehydes using a Wells–Dawson acid (H 6 P 2 W 18 O 62· 24H 2 O)

GP Romanelli, HJ Thomas, GT Baronetti, JC Autino

Index: Romanelli, Gustavo P.; Thomas, Horacio J.; Baronetti, Graciela T.; Autino, Juan C. Tetrahedron Letters, 2003 , vol. 44, # 6 p. 1301 - 1303

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Citation Number: 107

Abstract

Aromatic and aliphatic aldehydes are transformed in 1, 1-diacetates (acylals) in mild conditions, by a treatment with acetic anhydride and a Wells–Dawson acid (H6P2W18O62· 24H2O). gem-Diacetylation proceeds in Ac2O with a little as 1% mol Wells–Dawson acid at room temperature and under solventless conditions, obtaining very good to excellent yields (88–98%) of 1, 1-diacetates (19 examples). Neither 4-dimethylaminobenzaldehyde nor ...