Synthesis and biological evaluation of tetrahydropyridinepyrazoles ('PFPs') as inhibitors of STAT3 phosphorylation

…, G Sethi, K Mantelingu, A Bender, KS Rangappa

Index: Revanna; Srinivasa; Li, Feng; Siveen, Kodappully Sivaraman; Dai, Xiaoyun; Swamy, Shivananju Nanjunda; Bhadregowda; Sethi, Gautam; Mantelingu; Bender, Andreas; Ks, Rangappa MedChemComm, 2014 , vol. 5, # 1 p. 32 - 40

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Citation Number: 3

Abstract

The transcription factor STAT3 is constitutively overexpressed in many human tumors and hence represents a putative target for anticancer drug design. In this work, we describe the synthesis and biological evaluation of a novel chemotype, pyridine-fused pyrazoles ('PFPs') as inhibitors of STAT3 phosphorylation. The effect of the compounds synthesized was evaluated in cell proliferation assays of MCF-7 and HepG2 cancer cell lines and two of the ...