Novel calcium antagonists. Synthesis and structure-activity relationship studies of benzothiazoline derivatives

…, M Fujita, K Tabashi, Y Kawashima…

Index: Yamamoto, Koji; Fujita, Masanobu; Tabashi, Keizo; Kawashima, Yoichi; Kato, Eishin; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, p. 919 - 930

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Citation Number: 49

Abstract

A series of novel compounds having a benzothiazoline skeleton was studied for their structure-activity relationship (SAR) with respect to Ca2+ antagonistic activity. As test compounds, analogues of 3-acyl-2-arylbenzothiazolines (3) were synthesized. Benzothiazoline derivatives (3) exerted higher Ca2+ antagonistic activity than the corresponding thiazolidine derivatives (2). Effects of substituents R1-R4, the substitution ...