3, 4-Pentadienol was protected with ethyl vinyl ether and regioselectively (70%) deprotonated at the terminal position by treatment with BuLi in THF at low temperature. Starting from the so obtained lithium compound, Marasin (nona-6, 8-diyne-3, 4-dienol)(1a) and 9-Me-Marasin (deca-6, 8-diyne-3, 4-dienol)(1b) were prepared by two metal-mediated synthetic routes. Route A involves transmetallation of the lithium compound with LiCuBr2, ...
