Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents

SA Khanum, S Shashikanth, A Firdouse

Index: Khanum, Shaukath Ara.; D, Venu T.; Shashikanth, Sheena; Firdouse, Aiysha Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5351 - 5355

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Citation Number: 17

Abstract

Benzoylation of hydroxybenzophenones 1a–f affords substituted benzoyl phenyl benzoates 3a–f, which on Fries rearrangement using microwave irradiation led to a facile synthesis of solely dibenzoyl phenols 4a–f in excellent yield. The newly synthesized compounds were screened for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compound 4e showed more potent activity than the standard ...