Substituted 6, 7-dihydroimidazo [1, 2-a] purin-9 (4H)-ones

…, JP Yevich, JD Catt, D Owens, C Hanning…

Index: Temple Jr.; Yevich; Catt; Owens; Hanning; Covington; Seidehamel; Dungan Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1188 - 1198

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Citation Number: 25

Abstract

D. L. Temple, Jr.,* JP Yevich, J. D. Catt, D. Owens, C. Hanning, R. R. Covington, R. J. Seidehamel, and K. W. Dungan ... Research Laboratories, Mead Johnson Pharmaceuticals, Evansville, Indiana 47721. Received February 21, I980 ... The synthesis of a series of substituted 6,7-dihydroimidazo[l,2-a]purin-9(4H)-ones ... Theophylline (la) is currently recognized as the drug r7 R ... R 3 la, R, = R, = CH,; R, = H; X = CH b, R, = CH,; R, = 4-NO,C6H,CH,;