Abstract O6-(4-Nitrophenyl) inosine (la), O6-(4-nitrophenyl) guanosine (1c) and O6-(4- methylumbelliferonyl) inosine (2) were obtained by reaction of 6-chloro-9-(β-D- ribofuranosyl) purine (3a) or 2-amino-6-chloro-9-(β-D-ribofuranosyl) purine (3c) with sodium salts of 4-nitrophenol or 4-methylumbelliferone in N, N-dimethylformamide. Similarly, 6- chloro-9-(β-D-2, 3-isopropylideneribofuranosyl) purine (3b) was transformed to 2′, 3′-O ...