One-pot synthesis of 2-pyridones via chemo-and regioselective tandem blaise reaction of nitriles with propiolates

…, YO Ko, JY Hong, J Hong, H Shin, S Lee

Index: Ko, Young Ok; Chun, Yu Sung; Park, Cho-Long; Kim, Youngmee; Shin, Hyunik; Ahn, Sungho; Hong, Jongki; Lee, Sang-Gi Organic and Biomolecular Chemistry, 2009 , vol. 7, # 6 p. 1132 - 1136

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Citation Number: 38

Abstract

Pyridones are embedded as common structural units of many natural products and biologically active compounds.(1) As a result, the development of efficient synthetic methods for this class of heterocyclic compounds has become a long-standing subject in synthetic and medicinal chemistry.(2) The most commonly employed method is Michael addition of acetonitrile derivatives such as cyanoacetate ester, cyanoacetamide, or malonitrile to an appropriate α,β- ...