Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein

…, ML Hammond, PJ Sinclair, MS Anderson…

Index: Thompson, Christopher F.; Ali, Amjad; Quraishi, Nazia; Lu, Zhijian; Hammond, Milton L.; Sinclair, Peter J.; Anderson, Matt S.; Eveland, Suzanne S.; Guo, Qiu; Hyland, Sheryl A.; Milot, Denise P.; Sparrow, Carl P.; Wright, Samuel D. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 6 p. 424 - 427

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Citation Number: 6

Abstract

Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. Inhibition of cholesteryl ester transfer protein (CETP) has been shown to elevate HDL-C levels in human subjects. This letter describes the discovery of a novel and potent (< 100 nM IC50 for the ...