Some 2-Substituted Aminopurines and Purine Analogs1

RM Cresswell, T Strauss, GB Brown

Index: Cresswell,R.M. et al. J. Med. Chem., 1963 , vol. 6, p. 817 - 819

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Citation Number: 4

Abstract

Pa, b PI inelcslpto-'2-pipeiidinop~ i~ iiie (IT'b, 11= piperidiiio), which\ vas shown to be ineffective against c. arcoina S180 by Dr. H. c'. Reilly and against B82X and 1'815 Icukmiias by Dr., JH Bui~ heiial, was found by 111. I). Ai. Karnofsky to inhibit profoundly cleavage iii Saiid Dollar embryos at levels of 0.2 pg. ml. 4 The. remarkd) ly low toxicity of this conipouiid ill mice. 12&>. io0 mg. kg. with repeated daily ip dosagc, 17