Synthesis and antiviral activity of 2-substituted analogs of triciribine

…, JM Breitenbach, JC Drach, LB Townsend

Index: Porcari, Anthony R.; Ptak, Roger G.; Borysko, Katherine Z.; Breitenbach, Julie M.; Drach, John C.; Townsend, Leroy B. Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2171 - 2193

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Citation Number: 4

Abstract

Abstract Triciribine (TCN) and triciribine monophosphate (TCN-P) have antiviral and antineoplastic activity at low or submicromolar concentrations. In an effort to improve and better understand this activity, we have conducted a structure-activity relationship study to explore the effect of substitutions at the 2-position of triciribine. 2-Methyl-(2-Me-TCN), 2-ethyl- (2-Et-TCN), 2-phenyl-(2-Ph-TCN), 2-chloro-(2-Cl-TCN), and 2-aminotriciribine (2-NH2- ...