The Journal of Organic Chemistry

Synthesis of Potential Diuretic Agents. IV. Bromo Derivatives of 1, 2, 4-Benzothiadiazine 1, 1-Dioxide

JH SHORT, LEOR SWETT

Index: Short,J.H.; Swett,L.R. Journal of Organic Chemistry, 1961 , vol. 26, p. 3428 - 3431

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Citation Number: 3

Abstract

79, 21-128 (1957). sequence of reactions used for chloro derivatives. Chlorosulfonation of m- bromoaniline (1) gave a disulfonyl chloride which, when treated with am monia, led to 4- amino-Fi-bromo-l, 3-benzenedisulfon-amide (11). Cyclization of the latter with formic acid gave 6-hromo-'i-sulfamyl-2H-1, 2, 4-benzothia-diazine 1, l-dioxide (111). With formaldehyde, the product was 6-brom0-3, 4-dihydro-'i-suIfamyl-2H-1, 2, 4-benzothia. diazine 1, l-dioxide ...