Journal of the American Chemical Society

Ring-Opening Metathesis Polymerization with the Second Generation Hoveyda–Grubbs Catalyst: An Efficient Approach toward High-Purity Functionalized Macrocyclic …

A Blencowe, GG Qiao

Index: Blencowe, Anton; Qiao, Greg G. Journal of the American Chemical Society, 2013 , vol. 135, # 15 p. 5717 - 5725

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Citation Number: 13

Abstract

Herein, we present a facile and general strategy to prepare functionalized macrocyclic oligo (cyclooctene) s (cOCOEs) in high purity and high yield by exploiting the ring-opening metathesis polymerization (ROMP) intramolecular backbiting process with the commercially available second generation Hoveyda–Grubbs (HG2) catalyst. In the first instance, ROMP of 5-acetyloxycyclooct-1-ene (ACOE) followed by efficient quenching and removal of the ...