Continuous flow photocyclization of stilbenes–scalable synthesis of functionalized phenanthrenes and helicenes

Q Lefebvre, M Jentsch…

Index: Lefebvre, Quentin; Jentsch, Marc; Rueping, Magnus Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1883 - 1890

Full Text: HTML

Citation Number: 16

Abstract

Following the pioneering examples of Scholz [6] and Martin [7] in 1967, the photocyclization of stilbene derivatives under UV-light irradiation is now a classical method for the synthesis of phenanthrenes and helicene-like molecules [8]. However, the scalability of these reactions is limited by the required low concentration (~10 −3 mol·L −1 ) and usually long reaction times (>20 h). Therefore, most of the applications of this method are limited to small scale (<0.5 ...