Synthesis of 2, 3??dihydro??1, 3??thiazin??4 (1H)??ones and their remarkably facile recyclization to 2, 3??dihydropyrimidin??4 (1H)??ones

…, AN Chernega, VV Pyrozhenko, AV Bol'but…

Index: Vovk, Mykhaylo V.; Sukach, Volodymyr A.; Chernega, Alexander N.; Pyrozhenko, Volodymyr V.; Bol'But, Andriy V.; Pinchuk, Alexander M. Heteroatom Chemistry, 2005 , vol. 16, # 5 p. 426 - 436

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Citation Number: 13

Abstract

Abstract Functionalized 2, 3-dihydro-1, 3-thiazin-4 (1H)-one derivatives have been synthesized by cyclocondensation of 3-alkyl (aryl) amino-2-cyano-3-mercaptoacrylamides with aldehydes and ketones under acidic catalysis. 6-Alkyl (aryl) amino-5-cyano-2, 3-dihy- dro-1, 3-thiazin-4 (1H)-ones, when treated with a dilute solution of potassium hydroxide, are converted into the potassium salts of isomeric compounds, 1-alkyl-(aryl)-5-cyano-6- ...