2, 4-Diaryl benzofuro [3, 2-b] pyridine derivatives: design, synthesis, and evaluation of topoisomerase inhibitory activity and cytotoxicity

P Thapa, Y Jahng, PH Park, JG Jee…

Index: Thapa, Pritam; Jahng, Yurngdong; Park, Pil-Hoon; Jee, Jun-Goo; Kwon, Youngjoo; Lee, Eung-Seok Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 10 p. 3073 - 3082

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Citation Number: 7

Abstract

Abstract Designed and synthesized twenty-four 2, 4-diaryl benzofuro [3, 2-b] pyridine derivatives were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2- or 3-furyl, 2-or 3-thienyl, and 2-pyridyl were substituted at 2-or 4-position of central pyridine. Compounds 8, 12, 13, and 14, with 2-furyl either at 2-or 4-position of central pyridine ...