Optical resolution by preferential crystallization of 1, 1, 3, 3-tetramethylbutylammonium salt of N-formyl-DL-. ALPHA.-phenylglycine.

…, H Miyazaki, T Imai, M Sunami, H Kurokawa

Index: Shiraiwa, Tadashi; Miyazaki, Hideya; Imai, Tomoki; Sunami, Michio; Kurokawa, Hidemoto Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 661 - 666

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Citation Number: 8

Abstract

Infrared spectrum, solubility, and ternary phase diagram of solubility indicated that 1, 1, 3, 3- tetramethylbutylammonium salt (DL-TMB salt) of N-formyl-DL-α-phenylglycine is a conglomerate. In order to resolve DL-TMB salt efficiently, crystallization of D-and L-TMB salts was examined by free energy of critical nucleation in supersaturated solutions. Successive preferential crystallization of DL-TMB salt was experimented at 10° C for racemic solution ...