e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The Journal of Organic Chemistry
Carbomethoxylation of epichlorohydrin with cobalt carbonyl and glycidyltrimethylammonium halide co-catalysts. New synthesis of alkali-sensitive epoxides
JD McClure
Index: McClure,J.D. Journal of Organic Chemistry, 1967 , vol. 32, p. 3888 - 3894
Reaction of epichlorohydrin with carbon monoxide and methanol in the presence of dicobalt octacarbonyl and glycidyltrimethylammonium halide (I1 or 111) cocatalysts gives methyl 4chloro-3-hydroxybutyrate (I) in 53% yield. In the absence of I1 (or 111) the rate of formation of I is reduced and the yield of I is only 20%. A mechanism whose first step is the attack of the cobalt tetracarbonyl anion on I1 (or 111) is proposed to aocount for the catalytic activity ...
