Novel Heteroarotinoids as Potential Antagonists of Mycobacterium b ovis BCG

…, J Klucik, KD Berlin, PJ Brennan, D Kaur…

Index: Brown, Chad W.; Liu, Shengquan; Klucik, Jozef; Berlin, K. Darrell; Brennan, Patrick J.; Kaur, Devinder; Benbrook, Doris M. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1008 - 1017

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Citation Number: 29

Abstract

A series of 15 heteroarotinoids has been prepared and evaluated for activity against Mycobacterium bovis BCG with the thiourea-containing isoxyl (7)(0.5 μg/mL) as the standard. 2, 2, 4-Trimethyl-2 H-chromen-7-yl 4-(methoxycarbonyl) benzoate (8) displayed the most significant activity (2.0-4.0 μg/mL) in terms of the lowest concentration (μg/mL)(MIC, minimum inhibitory concentration) required to produce a 99% reduction in the number of ...