Stereoselective synthesis of 1, 4, 2??oxazaphosphorines as precursors of chiral α??aminophosphonic acids by intramolecular heterocyclization of β?? …

…, EY Davydova, IA Litvinov, AT Gubaidullin…

Index: Dimukhametov, Mudaris N.; Bajandina, Eugenija V.; Davydova, Elena Yu.; Litvinov, Igor A.; Gubaidullin, Aidar T.; Dobrynin, Alexey B.; Zyablikova, Tatyana A.; Alfonsov, Vladimir A. Heteroatom Chemistry, 2003 , vol. 14, # 1 p. 56 - 61

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Citation Number: 20

Abstract

Abstract The intramolecular version of nucleophilic additon of phosphites to imines was carried out for the first time taking as an example β-aldiminoalkylphosphites, formed from chlorophosphites and β-aldiminoalcohols [N-(benzylidene)-2-aminoethanol and R-(+)-N- (benzylidene)-2-aminobutanol-1]. In these reactions, stereoisomeric 1, 4, 2- oxazaphosphorines were obtained in good yields. R-(+)-N-(benzylidene)-2-aminobutanol- ...